Cheap Flights from Houston to Knoxville/Maryville (IAH to TYS)

Trade the sprawling Gulf Coast energy of Houston for the scenic foothills of East Tennessee with Globitude Travels. Whether you are headed to Knoxville for university events, a business trip, or an outdoor getaway near the Great Smoky Mountains, we bring you exceptional airfare choices. Book your flight from Houston to Knoxville/Maryville today with trusted carriers like Delta Air Lines and United Airlines.

📞 Call 1-856-513-6369

Exploring Knoxville and East Tennessee from Houston

Departing from George Bush Intercontinental Airport (IAH), flights arrive at McGhee Tyson Airport (TYS), conveniently situated between Knoxville and Maryville. East Tennessee welcomes visitors with four distinct seasons, featuring vibrant autumn foliage, crisp mountain winters, and warm, lush summers that invite outdoor exploration.

Knoxville pairs historic Appalachian charm with vibrant contemporary culture. Wander through Market Square and the Old City to experience regional craft breweries, traditional Southern comfort food, and lively live music. Across the river, Maryville provides a relaxed gateway to scenic parkways, hiking trails, and peaceful mountain retreats.

Money-saving tips for this route

Consider flying out on a Tuesday or Wednesday to secure the lowest base economy rates.
Book your tickets at least three to four weeks before your departure date to avoid peak pricing.
Compare fares on both Delta Air Lines and United Airlines through Globitude Travels to find the best match for your schedule and budget.
Reserve a rental car in advance at McGhee Tyson Airport if you plan to explore Maryville and the Great Smoky Mountains.

Frequently asked questions

Which airlines offer flights from Houston (IAH) to Knoxville/Maryville (TYS)?

Globitude Travels offers competitive economy fares on this route with Delta Air Lines starting from $221 and United Airlines starting from $257.

What are the departure and arrival airports for this route?

Flights depart from George Bush Intercontinental Airport (IAH) in Houston, Texas, and land at McGhee Tyson Airport (TYS), serving both Knoxville and Maryville, Tennessee.

Are flights from Houston to Knoxville typically nonstop or do they include stops?

Depending on the airline and itinerary selected, flights between Houston and Knoxville may operate nonstop or include a brief connection through major airline hub cities.

When is generally the most affordable time to book flights to Knoxville?

Booking flights four to six weeks in advance, particularly for travel during late winter or mid-week departure dates, generally yields the most affordable airfare on this route.

Can I book my Houston to Knoxville flight by phone with Globitude Travels?

Yes, you can call Globitude Travels directly to speak with an experienced travel agent who can help you secure the best available Delta or United flight options.

Related routes

Houston to Amman Houston to Atlanta Houston to Atlantic City Houston to Baltimore Houston to Bar Harbor Houston to Burbank Denver to Knoxville/Maryville New York to Knoxville/Maryville Portland to Knoxville/Maryville Richmond to Knoxville/Maryville All routes →

Why book with Globitude Travels

💸 Transparent pricing
The fare you see is all-inclusive — taxes and fees shown before you pay, never after.

🤝 Real travel experts
Every booking is reviewed by our team, and phone-only vendor deals can beat any online price.

🎧 24/7 human support
Before, during and after your trip — changes, cancellations and special requests handled by people.

🔒 Secure checkout
Encrypted payment, verified confirmation emails, and your PNR delivered as soon as the airline issues it.

Globitude Travels is an independent travel agency — call 1-856-513-6369 or use the search above to compare live fares on this route. See our terms, privacy policy, refund policy and service fees for full details, or contact us any time.

Page updated September 12, 2026 · fare data refreshed automatically from live flight searches.