Cheap Flights from Denver to Knoxville/Maryville (DEN to TYS)

Trade the high-altitude peaks of Denver for the charm of East Tennessee when you book your flight from Denver (DEN) to Knoxville/Maryville (TYS) with Globitude Travels. Whether you are visiting the vibrant Downtown Knoxville Market Square or exploring the nearby Great Smoky Mountains, our team helps you find competitive airfares for a seamless journey.

📞 Call 1-856-513-6369

Flying from Denver to Knoxville and Maryville

Traveling from Denver International Airport (DEN) to McGhee Tyson Airport (TYS) connects the Rocky Mountains to the foothills of the Great Smokies. Located just south of Knoxville in the Alcoa and Maryville area, TYS serves as the primary regional hub for East Tennessee. Flights on this route typically feature a brief layover at major connecting hubs across the central United States.

East Tennessee features a pleasant climate with four distinct seasons, highlighted by vivid autumn foliage and warm, sunny summers. Visitors to Knoxville and Maryville can sample famous regional barbecue, explore historical neighborhood streets, and enjoy easy access to outdoor recreation. Globitude Travels works to secure ideal routes so you can focus on enjoying your trip.

Money-saving tips for this route

Book your tickets three to four weeks in advance to secure optimal pricing on travel between Denver and East Tennessee.
Consider flying on a Tuesday or Wednesday to take advantage of lower mid-week fare rates.
Fly with flexible travel dates to easily compare and choose the most cost-effective connection times.
Contact Globitude Travels directly to inquire about special phone discounts and tailored flight packages.

Frequently asked questions

What airports serve flights from Denver to Knoxville/Maryville?

Flights depart from Denver International Airport (DEN) and arrive at McGhee Tyson Airport (TYS), located convenient to both Knoxville and Maryville, Tennessee.

Are direct flights available between Denver and McGhee Tyson Airport?

Direct service depends on seasonal carrier schedules, but most itineraries on this route involve one brief connection.

What is generally the cheapest month to fly from Denver to Knoxville?

Travel during the late winter and early spring months, outside of major holiday weeks, generally offers the lowest fares.

Can I book my DEN to TYS flight by phone?

Yes, you can call Globitude Travels directly to consult with a travel agent for personalized booking assistance and phone-only deals.

How close is McGhee Tyson Airport to Maryville and Knoxville?

McGhee Tyson Airport is conveniently situated about 5 miles north of downtown Maryville and 12 miles south of downtown Knoxville.

Related routes

↩ Knoxville/Maryville to Denver Denver to Atlanta Denver to Calgary Denver to Cancún Denver to Chicago Denver to Chicago Denver to Cincinnati / Covington Houston to Knoxville/Maryville New York to Knoxville/Maryville Portland to Knoxville/Maryville Richmond to Knoxville/Maryville All routes →

Why book with Globitude Travels

💸 Transparent pricing
The fare you see is all-inclusive — taxes and fees shown before you pay, never after.

🤝 Real travel experts
Every booking is reviewed by our team, and phone-only vendor deals can beat any online price.

🎧 24/7 human support
Before, during and after your trip — changes, cancellations and special requests handled by people.

🔒 Secure checkout
Encrypted payment, verified confirmation emails, and your PNR delivered as soon as the airline issues it.

Globitude Travels is an independent travel agency — call 1-856-513-6369 or use the search above to compare live fares on this route. See our terms, privacy policy, refund policy and service fees for full details, or contact us any time.

Page updated August 16, 2026 · fare data refreshed automatically from live flight searches.